The Complementary Roles of Dynamic Contrast Enhanced MRI and 18F-Fluorodeoxyglucose PET/CT for Imaging of Carotid Atherosclerosis
Identifieur interne : 004455 ( Main/Exploration ); précédent : 004454; suivant : 004456The Complementary Roles of Dynamic Contrast Enhanced MRI and 18F-Fluorodeoxyglucose PET/CT for Imaging of Carotid Atherosclerosis
Auteurs : Claudia Calcagno [États-Unis] ; Sarayu Ramachandran [États-Unis] ; David Izquierdo-Garcia [États-Unis] ; Venkatesh Mani [États-Unis] ; Antoine Millon [États-Unis] ; David Rosenbaum [France] ; Ahmed Tawakol [États-Unis] ; Mark Woodward [Australie] ; Jan Bucerius ; Erin Moshier [États-Unis] ; James Godbold [États-Unis] ; David Kallend [Suisse] ; Michael E. Farkouh [États-Unis, Canada] ; Valentin Fuster [États-Unis, Espagne] ; James Hf Rudd [Royaume-Uni] ; Zahi A. Fayad [États-Unis]Source :
- European journal of nuclear medicine and molecular imaging [ 1619-7070 ] ; 2013.
Abstract
Inflammation and neovascularization in vulnerable atherosclerotic plaques are key risk factors for severe clinical events. Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) are two non-invasive imaging techniques capable of quantifying plaque neovascularization and inflammatory infiltrate respectively. However, their mutual role in defining plaque vulnerability and their possible overlap has not been thoroughly investigated. Here, we study the relationship between DCE-MRI and 18F-FDG PET in the carotid arteries of 40 subjects with coronary heart disease (CHD) or CHD equivalent, recruited as a substudy of the dal-PLAQUE trial (NCT00655473).
The dal-PLAQUE trial was a multicenter study that evaluated dalcetrapib, a cholesteryl ester transfer protein modulator. Subjects underwent anatomical MRI, DCE-MRI and 18F-FDG PET. Only baseline imaging and biomarkers data (before randomization) from dal-PLAQUE were used as part of this substudy. Our primary goal was to evaluate the relationship between DCE-MRI and 18F-FDG PET data. As secondary endpoints, we evaluated the relationship between a) PET data and whole vessel anatomical MRI data, and b) DCE-MRI and matching anatomical MRI data. All correlations were estimated using a mixed linear model.
We found a significant inverse relationship between several perfusion indices by DCE-MRI and 18F-FDG uptake by PET. Regarding our secondary endpoints, there was a significant relationship between plaque burden measured by anatomical MRI with several perfusion indices by DCE-MRI and 18F-FDG uptake by PET. No relationship was found between plaque composition by anatomical MRI with DCEMRI or 18F-FDG PET metrics.
In this study we observed a significant, weak inverse relationship between inflammation measured as 18F-FDG uptake by PET and plaque perfusion by DCE-MRI. Our findings suggest that there may be a complex relationship between plaque inflammation and microvascularization during the different stages of plaque development. 18F-FDG PET and DCE-MRI may have complementary roles in identifying subjects at high risk for cardiovascular events in future clinical practice.
Url:
DOI: 10.1007/s00259-013-2518-4
PubMed: 23942908
PubMed Central: 3823642
Affiliations:
- Australie, Canada, Espagne, France, Royaume-Uni, Suisse, États-Unis
- Angleterre, Angleterre de l'Est, Communauté de Madrid, Massachusetts, Nouvelle-Galles du Sud, État de New York, Île-de-France
- Cambridge, Madrid, Paris, Sydney
- Université de Cambridge, Université de Sydney
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Martinos Center for Biomedical Imaging, Harvard University - MIT - Massachusetts General Hospital, Charlestown, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Athinoula A. Martinos Center for Biomedical Imaging, Harvard University - MIT - Massachusetts General Hospital, Charlestown, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mani, Venkatesh" sort="Mani, Venkatesh" uniqKey="Mani V" first="Venkatesh" last="Mani">Venkatesh Mani</name><affiliation wicri:level="2"><nlm:aff id="A1">Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Radiology, Mount Sinai School of Medicine, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Mount Sinai School of Medicine, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Millon, Antoine" sort="Millon, Antoine" uniqKey="Millon A" first="Antoine" last="Millon">Antoine Millon</name><affiliation wicri:level="2"><nlm:aff id="A1">Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Radiology, Mount Sinai School of Medicine, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Mount Sinai School of Medicine, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Rosenbaum, David" sort="Rosenbaum, David" uniqKey="Rosenbaum D" first="David" last="Rosenbaum">David Rosenbaum</name><affiliation wicri:level="3"><nlm:aff id="A4">Hopital Pitié Salpétrière, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hopital Pitié Salpétrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tawakol, Ahmed" sort="Tawakol, Ahmed" uniqKey="Tawakol A" first="Ahmed" last="Tawakol">Ahmed Tawakol</name><affiliation wicri:level="2"><nlm:aff id="A5">Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name><affiliation wicri:level="4"><nlm:aff id="A6">George Institute, University of Sydney, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>George Institute, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Bucerius, Jan" sort="Bucerius, Jan" uniqKey="Bucerius J" first="Jan" last="Bucerius">Jan Bucerius</name><affiliation><nlm:aff id="A7">Department of Nuclear Medicine, Maastricht University Medical Center, Maastricht; the Netherlands</nlm:aff><wicri:noCountry code="subfield">Maastricht; the Netherlands</wicri:noCountry></affiliation><affiliation><nlm:aff id="A8">Cardiovascular Research Institute Maastricht (CARIM), Maastricht; the Netherlands</nlm:aff><wicri:noCountry code="subfield">Maastricht; the Netherlands</wicri:noCountry></affiliation><affiliation><nlm:aff id="A9">Department of Nuclear Medicine, Rheinisch-Westfaelische Technische Hochschule Aachen, Aachen; Germany</nlm:aff><wicri:noCountry code="subfield">Aachen; Germany</wicri:noCountry></affiliation></author><author><name sortKey="Moshier, Erin" sort="Moshier, Erin" uniqKey="Moshier E" first="Erin" last="Moshier">Erin Moshier</name><affiliation wicri:level="2"><nlm:aff id="A10">Biostatistics Shared Research Facility, Mount Sinai School of Medicine, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biostatistics Shared Research Facility, Mount Sinai School of Medicine, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Godbold, James" sort="Godbold, James" uniqKey="Godbold J" first="James" last="Godbold">James Godbold</name><affiliation wicri:level="2"><nlm:aff id="A10">Biostatistics Shared Research Facility, Mount Sinai School of Medicine, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biostatistics Shared Research Facility, Mount Sinai School of Medicine, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kallend, David" sort="Kallend, David" uniqKey="Kallend D" first="David" last="Kallend">David Kallend</name><affiliation wicri:level="1"><nlm:aff id="A11">F. Hoffmann-La Roche Ltd, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>F. Hoffmann-La Roche Ltd, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Farkouh, Michael E" sort="Farkouh, Michael E" uniqKey="Farkouh M" first="Michael E" last="Farkouh">Michael E. Farkouh</name><affiliation wicri:level="2"><nlm:aff id="A12">Cardiovascular Institute, Mount Sinai School of Medicine, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Institute, Mount Sinai School of Medicine, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Peter Munk Cardiac Centre and Li Ka Shing Knowledge Institute, Toronto, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Peter Munk Cardiac Centre and Li Ka Shing Knowledge Institute, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Fuster, Valentin" sort="Fuster, Valentin" uniqKey="Fuster V" first="Valentin" last="Fuster">Valentin Fuster</name><affiliation wicri:level="2"><nlm:aff id="A12">Cardiovascular Institute, Mount Sinai School of Medicine, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Institute, Mount Sinai School of Medicine, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A14">The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>The Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Rudd, James Hf" sort="Rudd, James Hf" uniqKey="Rudd J" first="James Hf" last="Rudd">James Hf Rudd</name><affiliation wicri:level="4"><nlm:aff id="A15">Division of Cardiovascular Medicine, University of Cambridge, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cardiovascular Medicine, University of Cambridge</wicri:regionArea><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author><author><name sortKey="Fayad, Zahi A" sort="Fayad, Zahi A" uniqKey="Fayad Z" first="Zahi A" last="Fayad">Zahi A. Fayad</name><affiliation wicri:level="2"><nlm:aff id="A1">Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Radiology, Mount Sinai School of Medicine, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Mount Sinai School of Medicine, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A12">Cardiovascular Institute, Mount Sinai School of Medicine, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Institute, Mount Sinai School of Medicine, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">European journal of nuclear medicine and molecular imaging</title><idno type="ISSN">1619-7070</idno><idno type="eISSN">1619-7089</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Inflammation and neovascularization in vulnerable atherosclerotic plaques are key risk factors for severe clinical events. Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography (PET) are two non-invasive imaging techniques capable of quantifying plaque neovascularization and inflammatory infiltrate respectively. However, their mutual role in defining plaque vulnerability and their possible overlap has not been thoroughly investigated. Here, we study the relationship between DCE-MRI and <sup>18</sup>F-FDG PET in the carotid arteries of 40 subjects with coronary heart disease (CHD) or CHD equivalent, recruited as a substudy of the dal-PLAQUE trial (NCT00655473).</p></sec><sec id="S2"><title>Methods</title><p id="P2">The dal-PLAQUE trial was a multicenter study that evaluated dalcetrapib, a cholesteryl ester transfer protein modulator. Subjects underwent anatomical MRI, DCE-MRI and <sup>18</sup>F-FDG PET. Only baseline imaging and biomarkers data (before randomization) from dal-PLAQUE were used as part of this substudy. Our primary goal was to evaluate the relationship between DCE-MRI and <sup>18</sup>F-FDG PET data. As secondary endpoints, we evaluated the relationship between a) PET data and whole vessel anatomical MRI data, and b) DCE-MRI and matching anatomical MRI data. All correlations were estimated using a mixed linear model.</p></sec><sec id="S3"><title>Results</title><p id="P3">We found a significant inverse relationship between several perfusion indices by DCE-MRI and <sup>18</sup>F-FDG uptake by PET. Regarding our secondary endpoints, there was a significant relationship between plaque burden measured by anatomical MRI with several perfusion indices by DCE-MRI and <sup>18</sup>F-FDG uptake by PET. No relationship was found between plaque composition by anatomical MRI with DCEMRI or <sup>18</sup>F-FDG PET metrics.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">In this study we observed a significant, weak inverse relationship between inflammation measured as <sup>18</sup>F-FDG uptake by PET and plaque perfusion by DCE-MRI. Our findings suggest that there may be a complex relationship between plaque inflammation and microvascularization during the different stages of plaque development. <sup>18</sup>F-FDG PET and DCE-MRI may have complementary roles in identifying subjects at high risk for cardiovascular events in future clinical practice.</p></sec></div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Communauté de Madrid</li><li>Massachusetts</li><li>Nouvelle-Galles du Sud</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Cambridge</li><li>Madrid</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université de Cambridge</li><li>Université de Sydney</li></orgName></list><tree><noCountry><name sortKey="Bucerius, Jan" sort="Bucerius, Jan" uniqKey="Bucerius J" first="Jan" last="Bucerius">Jan Bucerius</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Calcagno, Claudia" sort="Calcagno, Claudia" uniqKey="Calcagno C" first="Claudia" last="Calcagno">Claudia Calcagno</name></region><name sortKey="Calcagno, Claudia" sort="Calcagno, Claudia" uniqKey="Calcagno C" first="Claudia" last="Calcagno">Claudia Calcagno</name><name sortKey="Farkouh, Michael E" sort="Farkouh, Michael E" uniqKey="Farkouh M" first="Michael E" last="Farkouh">Michael E. Farkouh</name><name sortKey="Fayad, Zahi A" sort="Fayad, Zahi A" uniqKey="Fayad Z" first="Zahi A" last="Fayad">Zahi A. Fayad</name><name sortKey="Fayad, Zahi A" sort="Fayad, Zahi A" uniqKey="Fayad Z" first="Zahi A" last="Fayad">Zahi A. Fayad</name><name sortKey="Fayad, Zahi A" sort="Fayad, Zahi A" uniqKey="Fayad Z" first="Zahi A" last="Fayad">Zahi A. Fayad</name><name sortKey="Fuster, Valentin" sort="Fuster, Valentin" uniqKey="Fuster V" first="Valentin" last="Fuster">Valentin Fuster</name><name sortKey="Godbold, James" sort="Godbold, James" uniqKey="Godbold J" first="James" last="Godbold">James Godbold</name><name sortKey="Izquierdo Garcia, David" sort="Izquierdo Garcia, David" uniqKey="Izquierdo Garcia D" first="David" last="Izquierdo-Garcia">David Izquierdo-Garcia</name><name sortKey="Mani, Venkatesh" sort="Mani, Venkatesh" uniqKey="Mani V" first="Venkatesh" last="Mani">Venkatesh Mani</name><name sortKey="Mani, Venkatesh" sort="Mani, Venkatesh" uniqKey="Mani V" first="Venkatesh" last="Mani">Venkatesh Mani</name><name sortKey="Millon, Antoine" sort="Millon, Antoine" uniqKey="Millon A" first="Antoine" last="Millon">Antoine Millon</name><name sortKey="Millon, Antoine" sort="Millon, Antoine" uniqKey="Millon A" first="Antoine" last="Millon">Antoine Millon</name><name sortKey="Moshier, Erin" sort="Moshier, Erin" uniqKey="Moshier E" first="Erin" last="Moshier">Erin Moshier</name><name sortKey="Ramachandran, Sarayu" sort="Ramachandran, Sarayu" uniqKey="Ramachandran S" first="Sarayu" last="Ramachandran">Sarayu Ramachandran</name><name sortKey="Ramachandran, Sarayu" sort="Ramachandran, Sarayu" uniqKey="Ramachandran S" first="Sarayu" last="Ramachandran">Sarayu Ramachandran</name><name sortKey="Tawakol, Ahmed" sort="Tawakol, Ahmed" uniqKey="Tawakol A" first="Ahmed" last="Tawakol">Ahmed Tawakol</name></country><country name="France"><region name="Île-de-France"><name sortKey="Rosenbaum, David" sort="Rosenbaum, David" uniqKey="Rosenbaum D" first="David" last="Rosenbaum">David Rosenbaum</name></region></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name></region></country><country name="Suisse"><noRegion><name sortKey="Kallend, David" sort="Kallend, David" uniqKey="Kallend D" first="David" last="Kallend">David Kallend</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Farkouh, Michael E" sort="Farkouh, Michael E" uniqKey="Farkouh M" first="Michael E" last="Farkouh">Michael E. Farkouh</name></noRegion></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Fuster, Valentin" sort="Fuster, Valentin" uniqKey="Fuster V" first="Valentin" last="Fuster">Valentin Fuster</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rudd, James Hf" sort="Rudd, James Hf" uniqKey="Rudd J" first="James Hf" last="Rudd">James Hf Rudd</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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